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Foundayo

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Eli Lilly’s retatrutide moves closer to a planned 2027 U.S. filing after completing its core Phase 3 programme for obesity, knee pain and sleep apnea. Representative image.
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Retatrutide development: Phase 3 results, 2027 FDA filing, TRIUMPH trials and what comes next

Eli Lilly and Company’s retatrutide programme has completed the core Phase 3 clinical package supporting planned submissions for obesity, knee osteoarthritis pain and obstructive sleep apnea. The investigational triple hormone receptor agonist is moving toward a U.S. filing in the first quarter of 2027 while additional studies test diabetes, cardiovascular and kidney outcomes, liver disease, chronic pain, maintenance treatment and its performance against tirzepatide.