Cellectis begins MELANI-01 clinical trial for UCARTCS1 in multiple myeloma

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Cellectis said that it has dosed the first patient in a phase 1  study – the MELANI-01 clinical trial to evaluate UCARTCS1, an allogeneic off-the-shelf CAR-T product candidate for the treatment of relapsed/refractory multiple myeloma (R/R MM).

The French gene therapy company began the phase 1 dose-escalation study after getting clearance from the US Food and Drug Administration (FDA) to advance the CAR-T product candidate into clinical development for the type of blood cancer.

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Based in Paris, Cellectis is engaged in developing immunotherapies based on gene-edited off-the-shelf CAR T-cells (UCART).

The French biopharma company said that the MELANI-01 clinical trial will assess the safety, expansion, persistence and clinical activity of UCARTCS1 cells in relapsed/refractory multiple myeloma.

Cellectis doses first patient in MELANI-01 clinical trial for UCARTCS1 in multiple myeloma

Cellectis doses first patient in MELANI-01 clinical trial for UCARTCS1 in multiple myeloma. Image courtesy of dream designs at FreeDigitalPhotos.net.

Dr. André Choulika – Chairman and CEO of Cellectis said: “This first patient dosing for our MELANI-01 clinical trial is an important advancement, as our team has worked tirelessly to develop and take the CS1 target from the lab to the clinic.

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“In taking this next clinical step, we look forward to deepening our understanding of UCARTCS1 as a potential new treatment option for relapsed/refractory multiple myeloma patients in the future.”

According to Cellectis, the MELANI-01 clinical trial is open currently at MD Anderson Cancer Center in Houston, Texas and also at Hackensack Meridian in New Jersey. Another site for the MELANI-01 clinical trial is planned to open at Weill Cornell Medicine in New York.

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