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London Stock Exchange

282 posts
Defence Holdings is building a UK software-led defence platform around sovereign AI, the Meridian accelerator and its first £226,000 Ministry of Defence contract. Representative image.
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Defence Holdings (LSE: ALRT) company profile: How the former Guild Esports listing pivoted into UK defence software

Defence Holdings PLC has transformed from the listed company formerly known as Guild Esports into an early-stage defence software and investment platform. Its first £226,000 UK Ministry of Defence contract and partnerships with Oracle and Whitespace provide initial validation, but the short contract duration, operating losses and rapid expansion of its share count leave the wider investment case unproven.
Avacta Group is advancing its pre|CISION tumour-targeted cancer platform through AVA6000 and AVA6103 as investors assess clinical validation, partnering prospects and funding risk. Representative image.
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Avacta Group (AIM: AVCT) company profile: Can pre|CISION make potent cancer drugs safer and more targeted?

Avacta Group plc is developing peptide drug conjugates intended to release potent anticancer payloads primarily within the tumour microenvironment. Early AVA6000 findings and the launch of the AVA6103 trial have strengthened the scientific case, but larger clinical studies, partnership funding and management of the remaining convertible bond will determine whether pre|CISION creates sustainable shareholder value.