Alterity Therapeutics launches phase 2 trial of MSA candidate ATH434


Alterity Therapeutics said that it has launched a phase 2 clinical trial of its lead candidate ATH434 in patients with multiple system atrophy (MSA).

According to the Australian biotech company, the mid-stage clinical trial is now open for patient enrolment in New Zealand.

Alterity Therapeutics believes that ATH434 lowers the toxic accumulation of α-synuclein, which is a pathological hallmark of multiple system atrophy. ATH434 is said to preserve nerve cells through the restoration of normal iron balance in the brain.

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The Australian biotech company said that ATH434 can potentially address the underlying pathology of multiple system atrophy and preserve function in patients.

David Stamler — Alterity Therapeutics CEO said: “The advancement of our ATH434 program underscores our commitment to bring a much needed treatment to individuals with MSA.

“The opening of enrolment for our Phase 2 in New Zealand is an important first step for this clinical program, and I am grateful to our team and our investigators who supported the launch of the trial. Over the course of this year, we will expand the trial into other regions globally.”

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