Xencor launches phase 1 trial of XmAb20717 in advanced solid tumors

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Xencor has launched a phase 1 clinical trial of its bispecific antibody XmAb20717, which is being developed for the treatment of multiple advanced solid tumors.

The California-based biopharma company has dosed the first patient in this regard in the early-stage human trial named XmAb20717-01 (DUET-2).

DUET-2 is a multiple-dose, dose-escalation trial that will determine the safety and tolerability, pharmacokinetics, pharmacodynamics, immunogenicity and preliminary anti-tumor activity of XmAb20717, which will be intravenously administered in patients with certain advanced solid tumors.

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According to Xencor, XmAb20717 simultaneously targets PD-1 and CTLA-4 immune checkpoints.

Xencor doses first patient in Phase 1 trial of XmAb20717 in advanced solid tumors.

Xencor doses first patient in Phase 1 trial of XmAb20717 in advanced solid tumors. Photo courtesy of Daino_16/Freeimages.com

Commenting on the phase 1 DUET-2 trial of XmAb20717, Paul Foster – chief medical officer at Xencor, said: “Built on the scaffold of Xencor’s XmAb bispecific Fc domain, XmAb20717 is the most advanced candidate in our suite of tumor microenvironment activators.

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“The dual blockade of PD-1 and CTLA-4 with XmAb20717 may promote superior T cell activation and proliferation compared to anti-PD-1 alone, and we look forward to studying its safety, tolerability and therapeutic activity in clinical trials.”

Xencor is looking to file investigational new drug applications for a couple of more tumor microenvironment activators – a PD-1 x ICOS bispecific antibody called XmAb23104 and a CTLA-4 x LAG-3 dual checkpoint inhibitor named XmAb22841 by the end of this year.

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Headquartered in Monrovia and founded in 1997, Xencor develops engineered monoclonal antibodies that are designed to target autoimmune diseases, asthma and allergic diseases and cancer.

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