Top U.S. stock market gainers: Hims & Hers, Upwork, and Oklo lead broad-based rally

The U.S. stock market surged on May 6, 2025, with multiple mid- and large-cap names posting double-digit percentage gains, signaling strong investor sentiment driven by earnings beats, policy speculation, and industry-specific catalysts. From tech-enabled services to clean energy and healthcare, the day’s top performers reflected broader themes of innovation, recovery, and targeted capital flows. Below is an in-depth look at all 25 top gainers, with analysis of individual stock drivers, valuation metrics, and institutional positioning.

Why Did Pony AI Inc. (PONY) Stock Rise on May 6, 2025?

Pony AI Inc. soared 47.63% to close at $14.32 on exceptionally high volume, with over 55 million shares traded—nearly nine times its three-month average. The self-driving technology company rallied after news broke of its strategic partnership with Uber Technologies to deploy robotaxis in the Middle East. This development positioned Pony AI as a leader in autonomous ride-hailing expansion outside China, revitalizing investor interest. With a market cap nearing $3.9 billion and no current earnings, Pony remains a speculative but high-momentum play in the AI mobility segment.

Why Did WeRide Inc. (WRD) Shares Jump?

WeRide Inc. advanced 31.68% to $9.02 amid similar enthusiasm surrounding autonomous vehicle collaborations. Its deepened partnership with Uber suggested cross-border validation of its tech stack and monetization capabilities. Trading volume surged to 48.9 million shares, well above average, as speculative capital rotated into the AV sector. Despite a year-to-date decline prior to this rally, sentiment flipped bullish following the joint venture announcement.

What Boosted Hims & Hers Health, Inc. (HIMS) Stock?

Hims & Hers Health gained 18.12%, closing at $49.47 after delivering robust quarterly results. The company beat Wall Street expectations with strong subscription growth, particularly in its mental health and dermatology verticals. With a P/E ratio of 78.52 and a market cap of $10.65 billion, Hims is increasingly being viewed as a high-growth digital health stock rather than a speculative tech play. Analysts upgraded the stock amid consistent top-line expansion and strong consumer retention metrics.

Why Was Upwork Inc. (UPWK) Among the Top Performing Stocks?

Upwork Inc. rose 18.02% to $15.72 as the freelance platform delivered a better-than-expected start to 2025. The company reported an improvement in gross bookings and operating leverage, which led to institutional accumulation. At a relatively low P/E of 9.47, the $2.1 billion company now trades at a discount compared to other gig economy peers, drawing value-oriented investors into the stock.

What Sent Regal Rexnord Corporation (RRX) Higher?

Regal Rexnord advanced 13.57% to $125.24 despite concerns about tariff-related margin pressures. The industrial automation and electric motor firm beat earnings estimates and posted strong free cash flow, offsetting investor fears. Its P/E of 42.6 suggests a premium valuation, but the stock was buoyed by upbeat guidance and signs of durable demand across its North American manufacturing base.

Why Did Oklo Inc. (OKLO) Gain Double Digits?

Oklo Inc. jumped 12.52% to $28.66 as investors responded to reports of the Biden administration exploring executive actions to accelerate nuclear energy deployment. The advanced fission startup, which remains pre-revenue, is seen as a strategic beneficiary of U.S. efforts to expand non-carbon energy sources. Its $4 billion valuation underscores the speculative, policy-sensitive nature of the nuclear sector in the current energy transition landscape.

What Drove UL Solutions Inc. (ULS) Stock Higher?

UL Solutions climbed 12.29% to $67.33 after reporting Q1 revenue of $705 million, up 5.2% year-over-year. The testing, inspection, and certification (TIC) provider continues to gain from the compliance wave across electronics, automotive, and medical device industries. With a market cap of $12 billion and a P/E ratio of 36.99, the stock appeals to growth investors betting on global regulatory tightening.

What Catalyzed Premier, Inc. (PINC)’s Surge?

Premier, Inc. rose 11.85% to $22.94 after it announced a $0.21 dividend and guided positively for FY25. The healthcare improvement company reported increasing adoption of its analytics platform and supply chain services. With a steep P/E of 50.98, the $2.1 billion company relies on recurring service revenues, making it attractive in a high-rate environment where earnings stability is prized.

Why Did Constellation Energy Corporation (CEG) Rally?

Constellation Energy jumped 10.29% to $273.82 following a mixed Q1 print. While EPS missed consensus, revenues beat forecasts, and the company reaffirmed its 2025 earnings range. As the largest supplier of carbon-free energy in the U.S., Constellation remains central to institutional ESG portfolios. The stock’s P/E ratio of 20.87 and market cap of $85.8 billion reflect its utility-like resilience coupled with long-term clean energy growth.

Why Was Aramark (ARMK) a Top Gainer?

Aramark gained 10.06% to $37.64 after beating earnings estimates, reporting adjusted EPS of $0.34 on revenue of $4.3 billion. The food services and facilities management firm benefited from strong demand in education and sports venue segments. At a $9.98 billion valuation and 28.95 P/E, Aramark is regaining investor trust post-spin-off of its uniform services division.

What Lifted Celanese Corporation (CE)?

Celanese rose 9.56% to $49.05 after highlighting long-term margin recovery in its specialty materials division. Despite a sharp 70% drop in its stock over the last 12 months, institutional buying resumed as the acetyls business showed signs of bottoming. The company trades without a valid trailing P/E, reflecting earnings compression but strong potential for a cyclical rebound.

Why Did Orla Mining Ltd. (ORLA) Rise?

Orla Mining climbed 9.29% to $11.76, continuing a three-month trend of strong gold sector inflows. With a 200.77% year-on-year gain and a P/E of 43.56, the mid-cap miner is being priced for continued earnings momentum amid resilient gold prices and production upgrades at its Camino Rojo project.

What Fueled Interparfums, Inc. (IPAR)’s Rally?

Interparfums gained 8.73% to $120.00 following a 5% increase in Q1 sales and reiterated full-year guidance. The fragrance company, with a $3.85 billion market cap and P/E of 21.54, is capitalizing on luxury consumer demand, particularly in European and Asian markets.

Why Did Neurocrine Biosciences, Inc. (NBIX) Gain?

Neurocrine rose 8.36% to $118.92 ahead of multiple investor conferences where analysts expect updates on its psychiatry and neurology drug pipelines. The biotech firm, with a $11.77 billion valuation and a 33.31 P/E, remains a core holding for growth-oriented healthcare funds.

What Helped United States Cellular Corporation (USM) Surge?

United States Cellular gained 8.16% to $63.09 after reaffirming its 5G rollout roadmap. Despite industry pressures, the company attracted buyers with a positive EBITDA outlook. With a market cap of nearly $5 billion, the stock has gained 75% in 12 months amid speculation of infrastructure monetization.

Why Did Air Lease Corporation (AL) Climb?

Air Lease advanced 8.02% to $52.67 on expectations of rising lease yields and growing aircraft demand. The lessor’s P/E of 9.21 and market cap of $5.89 billion offer value appeal as global carriers re-fleet in the post-pandemic travel rebound.

What Sparked Gains in SiriusPoint Ltd. (SPNT)?

SiriusPoint rose 7.48% to $19.54 amid strong reinsurance underwriting results and higher investment income. Its P/E of 18.79 and $2.28 billion market cap put it in a favorable light compared to peers amid a hardening insurance market.

Why Was YPF Sociedad Anónima (YPF) Up?

YPF climbed 7.40% to $30.18 as the Argentine energy company announced higher crude production volumes. Despite macro risks in Argentina, the firm is drawing institutional inflows tied to commodity price resilience. Its ultra-low P/E of 5.04 makes it attractive in EM energy plays.

What Boosted Telephone and Data Systems, Inc. (TDS)?

TDS gained 7.21% to $34.03, continuing momentum tied to its asset monetization strategy and broadband expansion plans. The company has surged 122% over the past year, and institutional flows suggest growing interest in mid-tier telcos.

Why Did FTAI Aviation Ltd. (FTAI) Rise?

FTAI rose 7.21% to $108.01 as aviation infrastructure investment regained traction. The company’s parts and engine leasing platform is seeing strong post-COVID demand. Despite no trailing P/E, its fundamentals point to scalable revenue expansion.

What Sent Eldorado Gold Corporation (EGO) Up?

Eldorado rose 7.09% to $20.40, driven by safe-haven gold flows and operational stability in Greece and Turkey. With an 11.59 P/E and a $4.2 billion cap, the miner is gaining institutional interest amid inflation hedging.

What Pushed Dorman Products, Inc. (DORM) Higher?

Dorman gained 6.99% to $122.99 following a robust Q1 driven by auto part sales to aftermarket distributors. The stock’s P/E of 18.72 and steady 35% annual return made it a magnet for quality-focused funds.

Why Did Fresenius Medical Care AG (FMS) Gain?

Fresenius rose 6.99% to $27.41 on strong European dialysis volumes and restructuring gains. The $16 billion healthcare firm trades at a P/E of 26.36, with recovery trends attracting healthcare ETFs.

What Propelled TIM S.A. (TIMB) Shares?

TIM S.A. climbed 6.95% to $17.38 on improved mobile ARPU and network expansion in Brazil. The company’s P/E of 13.9 offers growth-at-a-reasonable-price (GARP) appeal in the LatAm telecom sector.

Why Did Enpro Inc. (NPO) Perform Strongly?

Enpro rose 6.86% to $166.45 following earnings that beat consensus on strong engineered product margins. The firm’s 45.23 P/E is offset by high returns on capital and consistent demand in defense and semicon end markets.

Are U.S. Stock Market Gainers Set to Extend Their Rally?

The strong performances seen on May 6 suggest renewed investor confidence across high-growth and value segments. Institutional flows favored automation, healthcare, gold, and telecom, while speculative capital found avenues in AI and nuclear themes. With the Federal Reserve expected to maintain rates steady, earnings momentum, policy shifts (e.g., energy and tech regulation), and global economic stability will be key in sustaining upward trajectories.