Novartis presented compelling interim results from the Phase III ALIGN study evaluating the efficacy of atrasentan, an investigational oral selective endothelin A (ETA) receptor antagonist, in patients with IgA nephropathy (IgAN). This data was highlighted at the European Renal Association (ERA) Congress, showcasing a significant 36.1% reduction in proteinuria at 36 weeks compared to placebo, […]
Novartis has shared encouraging results from the Phase III APPLAUSE-IgAN study, revealing that Fabhalta (iptacopan) led to a significant 38.3% reduction in proteinuria, as measured by the 24-hour urine protein to creatinine ratio (UPCR), at 9 months compared to placebo. These findings, which signal potential in slowing kidney disease progression in IgA nephropathy (IgAN) patients, […]
Novartis has achieved a major milestone in the treatment of IgA nephropathy (IgAN), reporting a 38.3% reduction in proteinuria in a pivotal Phase III trial. The study, dubbed APPLAUSE-IgAN, tested Fabhalta (iptacopan), an investigational Factor B inhibitor, demonstrating not only effectiveness in reducing protein levels in urine—a key marker for kidney disease progression—but also a […]
