Alphamab Oncology enrols patients for KN026-203 phase 2 clinical trial

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Alphamab Oncology said that it has completed enrolling patients in China for its KN026-203 phase 2 clinical trial of the combination of KN026 and KN046 in the treatment of HER2-positive solid tumors.

While KN026 is a HER2 bispecific antibody developed by the Chinese clinical-stage biopharma company, KN046 is a PD-L1/CTLA-4 bispecific antibody, developed by Jiangsu Alphamab.

Alphamab Oncology expects to release an interim analysis of the KN026-203 phase 2 clinical trial in Q2 2022.

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According to Alphamab Oncology, KN026-203 is an open-label study to be held across 25 centers in China for assessing the efficacy and safety of the KN026, KN046 combo in 102 patients with HER2-positive GC/GEJ, breast cancer and other HER2-positive solid tumors.

Alphamab Oncology enrols patients for KN026-203 phase 2 clinical trial of KN026 and KN046 combo in HER2-positive solid tumors

Alphamab Oncology enrols patients for KN026-203 phase 2 clinical trial of KN026 and KN046 combo in HER2-positive solid tumors. Image courtesy of doodlartdotcom from Pixabay.

Professor Shen Lin from Peking University Cancer Hospital, the principal investigator of the KN026-203 clinical trial, said: “Over expression of HER2 occurs in multiple tumor types such as breast, gastric, and intestinal cancers. There are urgent needs to develop effective treatment for those tumors.

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“A number of preclinical and clinical studies have shown the potential efficacy of anti-HER2 therapy in combination with immunotherapy. Combination of KN026 and KN046 is a exploration with global edge and potential to change treatment landscape forHER2-positive tumor. We are looking forward the data from interim analysis to confirming clinical value of the combo.”


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