In a landmark development, Schrödinger, Inc. has entered into a multi-target research collaboration and expanded software licensing agreement with Novartis AG, potentially valued at up to $2.5 billion. This strategic alliance aims to leverage Schrödinger’s advanced computational platform to accelerate drug discovery and development across various therapeutic areas. Under the terms of the agreement, Schrödinger […]
Novartis has reached a pivotal moment in the treatment of rare kidney diseases with the US Food and Drug Administration (FDA) granting accelerated approval for Fabhalta (iptacopan), a novel therapy designed to reduce proteinuria in adults with primary immunoglobulin A nephropathy (IgAN). This rare, progressively debilitating condition affects the kidneys by attacking the glomeruli, the […]
Novartis presented compelling interim results from the Phase III ALIGN study evaluating the efficacy of atrasentan, an investigational oral selective endothelin A (ETA) receptor antagonist, in patients with IgA nephropathy (IgAN). This data was highlighted at the European Renal Association (ERA) Congress, showcasing a significant 36.1% reduction in proteinuria at 36 weeks compared to placebo, […]
Novartis has announced a significant move in the oncology sector with its agreement to acquire Mariana Oncology, a preclinical-stage biotechnology company based in Watertown, Massachusetts. The transaction, valued at approximately $1.75 billion, including milestone payments, underscores Novartis’s commitment to advancing its capabilities in radioligand therapies (RLTs), a promising area of cancer treatment. Details of the […]
In a significant revelation, Novartis Pharmaceuticals Corporation has announced the latest findings from the ALITHIOS open-label extension study. The data underscores the sustained efficacy of Kesimpta (ofatumumab), particularly for recently diagnosed, treatment-naïve individuals with relapsing multiple sclerosis (RMS). This group, defined as those who began treatment within three years of their initial diagnosis, experienced substantial […]
Novartis has shared encouraging results from the Phase III APPLAUSE-IgAN study, revealing that Fabhalta (iptacopan) led to a significant 38.3% reduction in proteinuria, as measured by the 24-hour urine protein to creatinine ratio (UPCR), at 9 months compared to placebo. These findings, which signal potential in slowing kidney disease progression in IgA nephropathy (IgAN) patients, […]
Novartis has achieved a major milestone in the treatment of IgA nephropathy (IgAN), reporting a 38.3% reduction in proteinuria in a pivotal Phase III trial. The study, dubbed APPLAUSE-IgAN, tested Fabhalta (iptacopan), an investigational Factor B inhibitor, demonstrating not only effectiveness in reducing protein levels in urine—a key marker for kidney disease progression—but also a […]
In a significant move within the pharmaceutical industry, Novartis has entered into an agreement to launch a voluntary public takeover offer to acquire MorphoSys AG, a Germany-based global biopharmaceutical company renowned for developing innovative medicines in oncology. This acquisition, valued at EUR 2.7 billion, or EUR 68 per share, marks a strategic step for Novartis […]
Novartis has revealed encouraging data from the Phase III REMIX-1 and REMIX-2 studies. The studies focused on remibrutinib, a highly selective, oral Bruton’s tyrosine kinase (BTK) inhibitor, in treating chronic spontaneous urticaria (CSU) in patients inadequately controlled by H1-antihistamines. Remarkably, remibrutinib met all primary and secondary endpoints at Week 12, showcasing its potential in CSU […]
Novartis, a global leader in immuno-dermatology and rheumatology, announced the U.S. Food and Drug Administration’s approval of Cosentyx (secukinumab) for treating adults with moderate to severe hidradenitis suppurativa (HS). This approval places Cosentyx as the only FDA-approved fully human biologic that targets interleukin-17A (IL-17A), a key cytokine involved in HS inflammation. Understanding Hidradenitis Suppurativa and […]