AstraZeneca’s Imfinzi demonstrates significant survival benefits in Phase 3 ADRIATIC trial

AstraZeneca’s Imfinzi demonstrates significant survival benefits in Phase 3 ADRIATIC trial

In a significant advancement for cancer treatment, AstraZeneca’s Imfinzi (durvalumab) has emerged as the first and only immunotherapy to show a survival benefit in a global Phase III trial for patients with limited-stage small cell lung cancer (LS-SCLC). The ADRIATIC Phase III trial unveiled positive high-level results, revealing that Imfinzi significantly improved both overall survival […]

AstraZeneca’s PACIFIC-2 Phase 3 trial for Imfinzi in NSCLC falls short of primary endpoint

AstraZeneca’s PACIFIC-2 Phase 3 trial for Imfinzi in NSCLC falls short of primary endpoint

In the latest development in oncology research, AstraZeneca’s PACIFIC-2 Phase III trial, involving Imfinzi (durvalumab) concurrently administered with platinum-based chemoradiotherapy (CRT), did not achieve statistical significance for its primary endpoint of progression-free survival (PFS) in treating patients with unresectable, Stage III non-small cell lung cancer (NSCLC). Imfinzi’s Established Role and PACIFIC-2’s Goals Despite this outcome, […]

AstraZeneca’s IMFINZI/IMJUDO shows sustained OS in Phase 3 liver cancer study

AstraZeneca’s IMFINZI/IMJUDO shows sustained OS in Phase 3 liver cancer study

AstraZeneca’s IMFINZI (durvalumab) combined with IMJUDO (tremelimumab-actl) has demonstrated an enduring overall survival (OS) benefit in patients with advanced hepatocellular carcinoma (HCC), according to the updated results from the HIMALAYA Phase 3 trial. An unparalleled one in four patients were still alive four years after treatment with this novel combination therapy, marking the longest survival […]

AstraZeneca reports positive results for phase 2 COAST trial of oleclumab and monalizumab

AstraZeneca reports positive results for phase 2 COAST trial of oleclumab and monalizumab

AstraZeneca has reported positive results from the COAST phase 2 trial of its oleclumab or monalizumab in combination with Imfinzi (durvalumab) in patients with non-small cell lung cancer (NSCLC). The pharma giant said that the mid-stage clinical trial showed the experimental combinations to have improved progression-free survival (PFS) as well as objective response rate (ORR). […]

AstraZeneca’s Imfinzi garners positive opinion from CHMP for NSCLC treatment

AstraZeneca’s Imfinzi garners positive opinion from CHMP for NSCLC treatment

AstraZeneca has reached a crucial milestone as the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has issued a positive opinion recommending the approval of Imfinzi (durvalumab) for the treatment of locally-advanced, unresectable non-small cell lung cancer (NSCLC). This recommendation paves the way for a new treatment option for […]