Arcellx, and Kite to jointly advance CART-ddBMCA for multiple myeloma

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Arcellx, a US-based clinical-stage biotechnology company, and Kite, a Gilead company, are partnering to co-develop and co-commercialize the former’s CART-ddBCMA, a late-stage product candidate.

CART-ddBCMA, currently in phase 2 clinical development, is intended for the treatment of patients with relapsed or refractory multiple myeloma.

and Kite will share development, clinical trial, and commercialization costs for CART-ddBCMA.

Post-closing Arcellx will receive a $225 million upfront payment and $100 million equity investment from Kite as well as up to $3.9 billion in total contingent payments.

Rami Elghandour — Arcellx Chairman and CEO said: “This collaboration marks a significant achievement for the myeloma field and Arcellx.

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“Combining our potentially best-in-class CART-ddBCMA therapy for with Kite’s global leadership in cell therapy provides the foundation for us to commercialize our therapy at scale.”

Arcellx and Kite will co-commercialize and share the profits in the US while Kite will commercialize the product and Arcellx will receive low to mid-teen royalties outside the US.

The transaction will enable Arcellx to continue independently advancing its development pipeline and researching new product candidates beyond myeloma.

Christi Shaw — Kite CEO said: “The collaboration with Arcellx enables Kite to expand into a new area of high unmet need and bring a potentially best-in-class cell therapy to help many patients.

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“Cell therapy has proven it can change the way is treated by creating a potentially curative therapy for an individual patient, engineered from their own T cells.”

CART-ddBCMA has received fast track, orphan drug, and regenerative medicine advanced therapy designations from the .

Anticipated to close in Q1 2023, the transaction is subject to customary closing conditions.


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